Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 5/20 | 0.50 |
| ▸ | RARB | P10826 | 4/20 | 0.50 |
| ▸ | RARG | P13631 | 4/20 | 0.50 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.38 |
| ▸ | CPT1A | P50416 | 1/20 | 0.38 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 2/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24885447 | 0.85 | ALDH1A1 (0.43) | RARARARBRARGSLC9A1LMNA | |
| SCHEMBL9142318 | 0.80 | LMNA (0.46) | RARARARBRARGLMNARXRA | |
| SCHEMBL15577372 | 0.77 | PGR (0.41) | RARARARBRARGCYP3A4MARK3 | |
| SCHEMBL31559289 | 0.77 | PGR (0.41) | RARARARBRARGCYP3A4MARK3 | |
| SCHEMBL15577510 | 0.77 | CYP19A1 (0.38) | RARARARBRARGSLC9A1LMNA | |
| SCHEMBL17254692 | 0.77 | PGR (0.40) | RARARARBRARGMARK3 | |
| SCHEMBL4781663 | 0.77 | POLB (0.50) | RARALMNACYP26A1CYP3A4CPT2 | |
| SCHEMBL16322116 | 0.74 | GAA (0.39) | RARARARBRARGLMNARXRA | |
| SCHEMBL16324015 | 0.73 | BACE1 (0.45) | SLC9A1MARK3 | |
| SCHEMBL31411806 | 0.72 | ELANE (0.55) | LMNACYP3A4CPT2CPT1ACPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008017465-A1 | BICYCLIC LACTAM DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-14 | — | — | WO | claimed |
| WO-2008017465-A1 | BICYCLIC LACTAM DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-14 | — | — | WO | disclosed |