Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781657 | 1.00 | HSD17B10 (0.42) | HSD17B10MAPK1PDK4KMT2AMEN1 | |
| SCHEMBL14281799 | 0.93 | PDK4 (0.38) | HSD17B10MAPK1PDK4KMT2AMEN1 | |
| SCHEMBL3808236 | 0.93 | PDK4 (0.42) | HSD17B10PDK4KMT2AMEN1ALDH1A1 | |
| SCHEMBL3808232 | 0.93 | PDK4 (0.42) | HSD17B10PDK4KMT2AMEN1ALDH1A1 | |
| SCHEMBL3808231 | 0.93 | PDK4 (0.42) | HSD17B10PDK4KMT2AMEN1ALDH1A1 | |
| SCHEMBL13315631 | 0.89 | HSD17B10 (0.42) | HSD17B10MAPK1PDK4KMT2AMEN1 | |
| SCHEMBL13315635 | 0.89 | HSD17B10 (0.42) | HSD17B10MAPK1PDK4KMT2AMEN1 | |
| SCHEMBL13349268 | 0.88 | HSD17B10 (0.42) | HSD17B10MAPK1PDK4KMT2AMEN1 | |
| SCHEMBL13349273 | 0.88 | HSD17B10 (0.42) | HSD17B10MAPK1PDK4KMT2AMEN1 | |
| SCHEMBL3808016 | 0.85 | SMN1; SMN2 (0.42) | HSD17B10MAPK1PDK4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760832-B1 | IMPROVED PROCESS FOR PREPARING 2-[(2E)-2-FLUORO-2-(3-PIPERIDINYLIDENE)ETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-22 | — | — | EP | disclosed |
| US-20150141652-A1 | PROCESS FOR PREPARING 2-[(2E)-2-FLUORO-2-(3-PIPERIDINYLIDENE)ETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE | JANSSEN PHARMACEUTICA NV (BE) | 2015-05-21 | — | — | US | disclosed |
| US-20150141652-A1 | PROCESS FOR PREPARING 2-[(2E)-2-FLUORO-2-(3-PIPERIDINYLIDENE)ETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE | JANSSEN PHARMACEUTICA NV (BE) | 2015-05-21 | — | — | US | disclosed |
| WO-2013045599-A1 | IMPROVED PROCESS FOR PREPARING 2-[(2E)-2-FLUORO-2-(3-PIPERIDINYLIDENE)ETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE | JANSSEN PHARMACEUTICA NV (BE) | 2013-04-04 | — | — | WO | disclosed |
| US-7732612-B2 | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | JANSSEN PHARMACEUTICA, N.V. (BE) | 2010-06-08 | — | — | US | disclosed |
| WO-2010056633-A2 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-20 | — | — | WO | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| US-20080009628-A1 | One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-10 | — | — | US | disclosed |
| WO-2008005670-A2 | ONE-POT CONDENSATION REDUCTION METHODS FOR PREPARING SUBSTITUTED ALLYLIC ALCOHOLS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008005670-A2 | ONE-POT CONDENSATION REDUCTION METHODS FOR PREPARING SUBSTITUTED ALLYLIC ALCOHOLS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-10 | — | — | WO | disclosed |
| US-20080009628-A1 | One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-10 | — | — | US | disclosed |
| US-20080009628-A1 | One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009628-A1 | One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols | ADH1A, ADH1C, TALDO1 | HSD17B10 302/4885MAPK1 4221/4885PDK4 1627/4885 |
| US-20090156577-A1 | 7-AMINO ALKYLIDENYL-HETEROCYCLIC QUINOLONES AND NAPHTHYRIDONES | NQO2, QRFPR, NQO1 | HSD17B10 3088/4885MAPK1 2916/4885PDK4 2423/4885 |
| US-20150141652-A1 | PROCESS FOR PREPARING 2-[(2E)-2-FLUORO-2-(3-PIPERIDINYLIDENE)ETHYL]-1H-ISOINDOLE-1,3(2H)-DIONE | DHPS, AZI2, QDPR | HSD17B10 3062/4885MAPK1 374/4885PDK4 1147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.