SCHEMBL4781749

SCHEMBL4781749

NNC(=O)C(N)=C1C(=O)N(CCc2ccccc2)c2ccccc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 10/20 0.56
PARK7 Q99497 5/20 0.56
ALDH2 P05091 4/20 0.56
ALDH3A1 P30838 4/20 0.56
PKM P14618 2/20 0.47
MAPT P10636 5/20 0.45
KDM4E B2RXH2 3/20 0.45
TDP1 Q9NUW8 1/20 0.45
CASP3 P42574 1/20 0.44
POLB P06746 2/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
RAB9A P51151 3/20 0.42
KMT2A Q03164 2/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
TAAR1 Q96RJ0 1/20 0.42
GAA P10253 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16799085 0.72 ALDH1A1 (1.00) ALDH1A1PARK7ALDH2ALDH3A1PKM
SCHEMBL12930286 0.70 CDC25A (0.67) ALDH1A1PARK7ALDH2ALDH3A1PKM
SCHEMBL2823268 0.70 ALDH1A1 (0.66) ALDH1A1PARK7ALDH2ALDH3A1PKM
SCHEMBL27887467 0.68 PARK7 (0.56) ALDH1A1PARK7ALDH2ALDH3A1PKM
SCHEMBL31048623 0.67 ALDH1A1 (0.66) ALDH1A1PARK7ALDH2ALDH3A1PKM
SCHEMBL29724090 0.67 CASP3 (0.86) ALDH1A1PARK7ALDH2ALDH3A1MAPT
SCHEMBL1142116 0.67 CASP3 (0.86) ALDH1A1PARK7ALDH2ALDH3A1MAPT
SCHEMBL13401827 0.65 ALDH1A1 (0.51) ALDH1A1PARK7ALDH2ALDH3A1PKM
SCHEMBL28137283 0.65 ALDH1A1 (0.69) ALDH1A1PARK7ALDH2ALDH3A1PKM
SCHEMBL2823271 0.65 ALDH1A1 (0.59) ALDH1A1PARK7ALDH2ALDH3A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008021250-A2 COMPOSITIONS AND METHODS FOR MODULATING APOPTOSIS IN CELLS OVER-EXPRESSING BCL-2 FAMILY MEMBER PROTEINS FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2008-02-21 WO disclosed