Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 12/20 | 0.67 |
| ▸ | GALK1 | P51570 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | IL1RN | P18510 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4733325 | 0.86 | SFRP1 (0.81) | SFRP1GALK1MEN1KMT2AEPHX2 | |
| SCHEMBL4781750 | 0.86 | SFRP1 (0.57) | SFRP1 | |
| SCHEMBL4783460 | 0.85 | SFRP1 (0.50) | SFRP1 | |
| SCHEMBL4785401 | 0.85 | SFRP1 (0.54) | SFRP1GALK1MEN1KMT2AEPHX2 | |
| SCHEMBL4781883 | 0.85 | SFRP1 (0.52) | SFRP1 | |
| SCHEMBL4785274 | 0.83 | SFRP1 (0.45) | SFRP1 | |
| SCHEMBL4785281 | 0.83 | SFRP1 (0.45) | SFRP1 | |
| SCHEMBL4783391 | 0.82 | SFRP1 (0.46) | SFRP1 | |
| SCHEMBL4783395 | 0.82 | SFRP1 (0.46) | SFRP1 | |
| SCHEMBL4734355 | 0.82 | SFRP1 (0.75) | SFRP1GALK1MEN1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |