Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | IL1RN | P18510 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GALK1 | P51570 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782531 | 0.93 | SFRP1 (0.53) | SFRP1ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4730823 | 0.86 | SFRP1 (0.62) | SFRP1ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4783541 | 0.85 | SFRP1 (0.39) | SFRP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL4784223 | 0.85 | HTR1A (0.42) | SFRP1 | |
| SCHEMBL4781874 | 0.85 | SFRP1 (0.67) | SFRP1ALDH1A1KMT2AMEN1EPHX2 | |
| SCHEMBL4802468 | 0.84 | HTR1A (0.46) | — | |
| SCHEMBL14207899 | 0.82 | HTR6 (0.43) | ALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL4784467 | 0.82 | HTR6 (0.42) | KMT2AMEN1LMNA | |
| SCHEMBL14208234 | 0.81 | HTR6 (0.49) | SFRP1ALDH1A1MAPT | |
| SCHEMBL4783673 | 0.81 | CCR8 (0.51) | ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |