Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14209100 | 0.88 | SIGMAR1 (0.43) | HTR6SIGMAR1ALOX15TSHRSFRP1 | |
| SCHEMBL4780973 | 0.85 | SIGMAR1 (0.41) | HTR6SIGMAR1ALOX15TSHRSFRP1 | |
| SCHEMBL14208706 | 0.78 | TSHR (0.44) | HTR6TSHR | |
| SCHEMBL4783073 | 0.78 | HTR6 (0.45) | HTR6 | |
| SCHEMBL4784579 | 0.78 | TDP1 (0.54) | HTR6TSHRMAPT | |
| SCHEMBL4781064 | 0.78 | HTR6 (0.43) | HTR6TSHRMAPT | |
| SCHEMBL4785064 | 0.76 | TSHR (0.48) | HTR6TSHR | |
| SCHEMBL4781621 | 0.76 | HTR6 (0.41) | HTR6TSHR | |
| SCHEMBL4783164 | 0.76 | TSHR (0.42) | HTR6TSHR | |
| SCHEMBL4783865 | 0.76 | TBXAS1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |