Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 16/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4782095 | 0.78 | HTR6 (0.48) | HTR6HTR2AMEN1KMT2ACYP3A4 | |
| SCHEMBL4781064 | 0.78 | HTR6 (0.43) | HTR6 | |
| SCHEMBL4784579 | 0.78 | TDP1 (0.54) | HTR6MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL4782487 | 0.78 | HTR6 (0.48) | HTR6 | |
| SCHEMBL4782093 | 0.77 | NPC1 (0.48) | HTR6MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4783408 | 0.77 | HTR6 (0.47) | HTR6HTR2APLK1MEN1KMT2A | |
| SCHEMBL4783865 | 0.76 | TBXAS1 (0.48) | SMN1; SMN2 | |
| SCHEMBL4785354 | 0.74 | MAPK1 (0.41) | HTR6DRD2HTR2APLK1MEN1 | |
| SCHEMBL4782935 | 0.73 | ALDH1A1 (0.43) | HTR6 | |
| SCHEMBL14208209 | 0.73 | HTR6 (0.54) | HTR6DRD2HTR2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |