Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 8/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 7/20 | 0.38 |
| ▸ | ABL1 | P00519 | 6/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780120 | 0.92 | DDR1 (0.35) | DDR2DDR1ABL1BCRBRAF | |
| SCHEMBL4778554 | 0.82 | DDT (0.42) | — | |
| SCHEMBL4780132 | 0.82 | RAF1 (0.40) | DDR2DDR1ABL1BCRBRAF | |
| SCHEMBL4779207 | 0.81 | NR1I2 (0.38) | — | |
| SCHEMBL4783994 | 0.79 | EGFR (0.33) | — | |
| SCHEMBL4783352 | 0.79 | MAPK14 (0.36) | BRAFCTSLCTSSCTSK | |
| SCHEMBL4782091 | 0.78 | BRAF (0.32) | BRAF | |
| SCHEMBL4782897 | 0.77 | DDT (0.40) | ABL1BCRBRAF | |
| SCHEMBL4783359 | 0.76 | MAPK14 (0.35) | NTRK1NTRK3NTRK2BRAF | |
| SCHEMBL4781339 | 0.75 | BRAF (0.43) | BRAFCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |