Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 10/20 | 0.37 |
| ▸ | RAF1 | P04049 | 6/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781149 | 0.91 | PLAU (0.40) | MAPK14PLAUBRAFRAF1ACLY | |
| SCHEMBL4783679 | 0.89 | MAPK14 (0.48) | MAPK14PLAUBRAFRAF1 | |
| SCHEMBL4782308 | 0.87 | PLAU (0.41) | MAPK14PLAUBRAFRAF1 | |
| SCHEMBL4781359 | 0.84 | ACKR3 (0.47) | PLAUBRAFRAF1WDR5 | |
| SCHEMBL4778219 | 0.84 | NAPEPLD (0.40) | MAPK14PLAUBRAFRAF1PIK3CB | |
| SCHEMBL4782767 | 0.83 | CNR2 (0.42) | MAPK14PLAUBRAFRAF1PIK3CB | |
| SCHEMBL4782171 | 0.83 | PLAU (0.38) | MAPK14PLAUBRAFRAF1WDR5 | |
| SCHEMBL4782131 | 0.83 | PLAU (0.38) | MAPK14PLAUBRAFRAF1GPR183 | |
| SCHEMBL4780442 | 0.83 | PLAU (0.38) | PLAUBRAFRAF1PIK3CD | |
| SCHEMBL4779984 | 0.81 | ACKR3 (0.41) | PLAUBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008021388-A1 | HETEROARYL DERIVATIVES AS CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-02-21 | — | — | WO | disclosed |