Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA7 | P43166 | 3/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5146133 | 0.78 | HTR6 (0.46) | HTR6CA12CA1CA2CA7 | |
| SCHEMBL11692937 | 0.75 | TSHR (0.45) | HTR6GAASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL3414041 | 0.75 | CYP3A4 (0.36) | HTR6GAACA12CA1CA2 | |
| SCHEMBL458583 | 0.75 | TTR (0.41) | HTR6GAACA12CA1CA2 | |
| SCHEMBL28690137 | 0.74 | HTR6 (0.57) | HTR6GAACA12CA1CA2 | |
| SCHEMBL30751995 | 0.70 | HTR6 (1.00) | HTR6GAACA12CA1CA2 | |
| SCHEMBL395274 | 0.70 | HTR6 (1.00) | HTR6GAACA12CA1CA2 | |
| Benzenesulfonamide SCHEMBL10582463 | 0.69 | CA2 (0.80) | HTR6GAACA12CA1CA2 | |
| SCHEMBL7563077 | 0.68 | GBA1 (0.31) | ALDH1A1KDM4E | |
| SCHEMBL315684 | 0.68 | HTR6 (0.54) | HTR6GAACA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008061160-A1 | USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS | PHARMACYCLICS, INC. (US) | 2008-05-22 | — | — | WO | disclosed |