Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7474879 | 0.77 | CA2 (0.41) | HTR6CA1CA2CA7CA9 | |
| SCHEMBL4602519 | 0.77 | CA1 (0.38) | HTR6CA1CA2CA7CA9 | |
| SCHEMBL5146133 | 0.74 | HTR6 (0.46) | HTR6CA1CA2CA7CA9 | |
| SCHEMBL4783755 | 0.74 | HTR6 (0.53) | HTR6GAACA1CA2CA7 | |
| SCHEMBL1905580 | 0.73 | SMN1; SMN2 (0.55) | CA2CA7CA9CA12CA14 | |
| SCHEMBL6913555 | 0.73 | HTR6 (1.00) | HTR6CA1CA2CA7CA9 | |
| SCHEMBL11692937 | 0.71 | TSHR (0.45) | HTR6GAAGFERPOLBTSHR | |
| SCHEMBL28699989 | 0.69 | HTR6 (0.65) | HTR6GAATP53KDM4EUSP2 | |
| SCHEMBL5451015 | 0.69 | HTR6 (0.65) | HTR6GAATP53KDM4EUSP2 | |
| SCHEMBL10787915 | 0.68 | HTR6 (0.64) | HTR6GAACA9CA12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114127062-A | Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta | 伊迪亚生物科学有限公司 | 2022-03-01 | — | — | CN | disclosed |