Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740581 | 0.76 | PDE3B (0.41) | ACACBALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4740254 | 0.72 | RAB9A (0.41) | ACACBALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4742022 | 0.68 | OPRK1 (0.39) | ALDH1A1MAPTLMNANPC1KDM4E | |
| SCHEMBL22445772 | 0.68 | ALDH1A1 (0.48) | ALDH1A1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL698276 | 0.66 | MAPK1 (0.56) | ALDH1A1MAPTSMN1; SMN2LMNAMAPK1 | |
| SCHEMBL3932256 | 0.66 | ALDH1A1 (0.45) | ALDH1A1MAPTLMNAGAAKDM4E | |
| SCHEMBL3929979 | 0.66 | BDKRB1 (0.41) | ALDH1A1RAB9ATSHRSMN1; SMN2MAPK1 | |
| SCHEMBL4784194 | 0.65 | BDKRB1 (0.38) | ACACBALDH1A1RAB9ATSHRSMN1; SMN2 | |
| SCHEMBL22445813 | 0.65 | SMN1; SMN2 (0.46) | ALDH1A1MAPTRAB9ASMN1; SMN2LMNA | |
| SCHEMBL7056273 | 0.64 | CYP2C9 (0.50) | ALDH1A1MAPTRAB9ATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008085119-A1 | NEW PYRIDINE ANALOGUES VIII 518 | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |