Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 7/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783936 | 0.89 | KDM4E (0.46) | KDM4EMAPTRAB9AHTR6PRMT5 | |
| SCHEMBL4781064 | 0.89 | HTR6 (0.43) | KDM4EMAPTRAB9AHTR6PRMT5 | |
| SCHEMBL4785772 | 0.88 | HTR6 (0.45) | KDM4EMAPTRAB9AHTR6PRMT5 | |
| SCHEMBL14207924 | 0.88 | HTR6 (0.43) | KDM4EMAPTRAB9AHTR6PRMT5 | |
| SCHEMBL4782431 | 0.88 | HTT (0.43) | KDM4EMAPTRAB9AHTR6PRMT5 | |
| SCHEMBL4784743 | 0.86 | HTR6 (0.41) | KDM4EMAPTRAB9AHTR6PRMT5 | |
| SCHEMBL4784058 | 0.86 | HTR6 (0.41) | KDM4EMAPTRAB9AHTR6PRMT5 | |
| SCHEMBL4784291 | 0.85 | TDP1 (0.54) | HTR6MEN1KMT2AHTTLMNA | |
| SCHEMBL4780521 | 0.83 | TBXAS1 (0.48) | PRMT5WDR77TDP1 | |
| SCHEMBL4616670 | 0.76 | MEN1 (0.56) | KDM4EMAPTRAB9APRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |