Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4781064 | 0.87 | HTR6 (0.43) | HTR6KDM4EMAPTRAB9AHTT | |
| SCHEMBL4785325 | 0.86 | TDP1 (0.51) | HTR6LMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL14207924 | 0.86 | HTR6 (0.43) | HTR6KDM4EMAPTRAB9ALMNA | |
| SCHEMBL4785772 | 0.86 | HTR6 (0.45) | HTR6KDM4EMAPTRAB9ALMNA | |
| SCHEMBL4784044 | 0.86 | KDM4E (0.44) | HTR6KDM4EMAPTRAB9ALMNA | |
| SCHEMBL4783936 | 0.85 | KDM4E (0.46) | HTR6KDM4EMAPTRAB9ALMNA | |
| SCHEMBL4782361 | 0.84 | TBXAS1 (0.46) | SMN1; SMN2 | |
| SCHEMBL4782431 | 0.83 | HTT (0.43) | HTR6KDM4EMAPTRAB9ALMNA | |
| SCHEMBL4784058 | 0.83 | HTR6 (0.41) | HTR6KDM4EMAPTRAB9ALMNA | |
| SCHEMBL4783079 | 0.81 | AKR1C3 (0.45) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |