Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 13/20 | 0.57 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738893 | 0.88 | SMO (0.47) | SMONR3C1 | |
| SCHEMBL27721784 | 0.82 | NR3C1 (0.56) | NR3C1PGR | |
| SCHEMBL4123094 | 0.82 | NR3C1 (0.56) | NR3C1PGR | |
| SCHEMBL4853828 | 0.77 | SMO (0.59) | SMONR3C1PGR | |
| SCHEMBL1360978 | 0.74 | SMO (0.66) | SMONR3C1 | |
| SCHEMBL4737912 | 0.73 | NR3C1 (0.72) | SMONR3C1PGR | |
| SCHEMBL1361796 | 0.73 | SMO (0.66) | SMONR3C1 | |
| SCHEMBL1360932 | 0.70 | SMO (0.61) | SMONR3C1PGR | |
| SCHEMBL995999 | 0.69 | LIPG (0.45) | — | |
| SCHEMBL24282902 | 0.69 | SMO (0.46) | SMONR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079073-A1 | INDAZOLYL SULPHONAMIDE DERIVATIVES FOR THE TREATMENT OF GLUCOCORTICOID RECEPTOR MEDIATED DISORDERS | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | WO | disclosed |