Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 8/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4785325 | 0.87 | TDP1 (0.51) | MAPK1KMT2ATDP1ALDH1A1USP2 | |
| SCHEMBL4782630 | 0.83 | KMT2A (0.48) | AKR1C3MAPK1KMT2ATDP1ALDH1A1 | |
| SCHEMBL4782361 | 0.83 | TBXAS1 (0.46) | KMT2ATDP1 | |
| SCHEMBL4782672 | 0.81 | ALDH1A1 (0.37) | ALDH1A1PTGES | |
| SCHEMBL4784743 | 0.81 | HTR6 (0.41) | ALDH1A1MAPT | |
| SCHEMBL4783275 | 0.77 | SMN1; SMN2 (0.49) | — | |
| SCHEMBL4784746 | 0.77 | LMNA (0.39) | KMT2AMAPT | |
| SCHEMBL4781750 | 0.77 | SFRP1 (0.57) | SFRP1 | |
| SCHEMBL4784750 | 0.76 | NSD2 (0.46) | AKR1C3ALDH1A1MAPTHDAC2HDAC8 | |
| SCHEMBL4785309 | 0.76 | HTR6 (0.43) | KMT2ATDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |