Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783875 | 0.85 | HTR6 (0.56) | HTR6 | |
| SCHEMBL4782882 | 0.84 | KMT2A (0.43) | KMT2AHTR6MEN1TSHRSMN1; SMN2 | |
| SCHEMBL4802468 | 0.83 | HTR1A (0.46) | HTR6 | |
| SCHEMBL4784203 | 0.83 | HTR6 (0.43) | HTR6 | |
| SCHEMBL4782045 | 0.83 | HTR6 (0.45) | MAPTHTR6ALDH1A1 | |
| SCHEMBL14207899 | 0.83 | HTR6 (0.43) | KMT2AHTR6MEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4784467 | 0.82 | HTR6 (0.42) | KMT2AHTR6MEN1SMN1; SMN2 | |
| SCHEMBL4784470 | 0.82 | HTR6 (0.42) | KMT2AHTR6IKBKB | |
| SCHEMBL4781961 | 0.81 | HTR6 (0.42) | HTR6 | |
| SCHEMBL4784223 | 0.80 | HTR1A (0.42) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |