Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784929 | 0.93 | ALDH1A1 (0.45) | ALDH1A1LMNAHTTHTR6L3MBTL1 | |
| SCHEMBL4785654 | 0.90 | TBXAS1 (0.46) | TDP1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL4784291 | 0.87 | TDP1 (0.54) | TDP1ALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL4780287 | 0.87 | ALDH1A1 (0.48) | TDP1ALDH1A1HTR6TP53MEN1 | |
| SCHEMBL4782431 | 0.86 | HTT (0.43) | TDP1ALDH1A1LMNAHTTHTR6 | |
| SCHEMBL4784579 | 0.85 | TDP1 (0.54) | TDP1ALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL4782126 | 0.83 | KEAP1 (0.44) | ALDH1A1LMNASMN1; SMN2HTTHTR6 | |
| SCHEMBL4783597 | 0.83 | TDP1 (0.51) | TDP1ALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL4785325 | 0.83 | TDP1 (0.51) | TDP1ALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL4784239 | 0.83 | MEN1 (0.48) | TDP1ALDH1A1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |