Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | NSD2 | O96028 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4780287 | 0.94 | ALDH1A1 (0.48) | ALDH1A1SFRP1HTR6KDM4EMAPK1 | |
| SCHEMBL4782569 | 0.93 | TDP1 (0.51) | ALDH1A1HTR6HTTL3MBTL1LMNA | |
| SCHEMBL4785654 | 0.91 | TBXAS1 (0.46) | ALDH1A1HTT | |
| SCHEMBL4782126 | 0.89 | KEAP1 (0.44) | ALDH1A1HTR6NSD2HTTL3MBTL1 | |
| SCHEMBL4782431 | 0.86 | HTT (0.43) | ALDH1A1MAPTHTR6HTTKDM4E | |
| SCHEMBL4784750 | 0.84 | NSD2 (0.46) | ALDH1A1SFRP1PRMT1MAPTHTR6 | |
| SCHEMBL4785064 | 0.82 | TSHR (0.48) | ALDH1A1HTR6L3MBTL1TSHRMAPK1 | |
| SCHEMBL4781621 | 0.82 | HTR6 (0.41) | HTR6TSHR | |
| SCHEMBL4783889 | 0.81 | BRD4 (0.43) | HTR6 | |
| SCHEMBL4783163 | 0.80 | IDE (0.53) | ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | claimed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |
| WO-2008060998-A1 | INDOLE SULFONAMIDES AS SFRP-1 MODULATORS | WYETH (US) | 2008-05-22 | — | — | WO | disclosed |