Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 3/20 | 0.49 |
| ▸ | WNT3A | P56704 | 3/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 4/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784496 | 0.91 | CES2 (0.43) | CTNNB1WNT3ACES2CES1SMYD3 | |
| SCHEMBL10407674 | 0.76 | CTNNB1 (0.61) | CTNNB1WNT3ASMYD3HDAC4MRGPRX4 | |
| SCHEMBL18641648 | 0.74 | CTNNB1 (0.56) | CTNNB1WNT3ASMYD3HDAC4MRGPRX4 | |
| SCHEMBL4734952 | 0.74 | MAOB (0.40) | CES2CES1MAOB | |
| SCHEMBL351400 | 0.74 | CTNNB1 (0.64) | CTNNB1WNT3ASMYD3HDAC4MRGPRX4 | |
| SCHEMBL3866171 | 0.74 | CTNNB1 (0.59) | CTNNB1WNT3ASMYD3HDAC4MRGPRX4 | |
| SCHEMBL1257050 | 0.73 | CTNNB1 (0.58) | CTNNB1WNT3ASMYD3HDAC4MRGPRX4 | |
| SCHEMBL19160022 | 0.73 | CTNNB1 (0.58) | CTNNB1WNT3ASMYD3HDAC4MRGPRX4 | |
| SCHEMBL1347343 | 0.73 | CTNNB1 (0.58) | CTNNB1WNT3ASMYD3HDAC4MRGPRX4 | |
| SCHEMBL29540656 | 0.73 | CTNNB1 (0.58) | CTNNB1WNT3ASMYD3HDAC4MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |