Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FADS1 | O60427 | 6/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686631 | 0.82 | FADS1 (0.59) | FADS1KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL27877680 | 0.78 | CNR1 (0.43) | CYP1A1CYP1A2CYP1B1KMT2AMAPT | |
| SCHEMBL28066532 | 0.78 | CYP3A4 (0.60) | CYP1A2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL3185782 | 0.77 | CYP2A6 (0.36) | ALDH1A1TDP1GRIK1 | |
| SCHEMBL30342506 | 0.76 | MEN1 (0.68) | FADS1CYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL3951892 | 0.76 | MEN1 (0.68) | FADS1CYP1A2KMT2AMAPTMEN1 | |
| SCHEMBL3038796 | 0.76 | HSD17B10 (0.57) | CYP1A2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL27668399 | 0.75 | TDP2 (0.62) | KMT2AMAPTMEN1ALDH1A1LMNA | |
| SCHEMBL30080248 | 0.74 | MEN1 (0.54) | CYP1A1CYP1A2CYP1B1KMT2AMAPT | |
| SCHEMBL11349013 | 0.73 | ADRA2A (0.38) | KMT2AMAPTMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |