Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.55 |
| ▸ | TSHR | P16473 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3185782 | 0.87 | CYP2A6 (0.36) | HSD17B10ALDH1A1ALOX12TSHRTDP1 | |
| SCHEMBL28861825 | 0.77 | HPGD (0.52) | HSD17B10ALDH1A1ALOX12TSHRTDP1 | |
| SCHEMBL8418943 | 0.77 | KDM1A (0.41) | KMT2AMEN1HPGDCYP2E1CYP2A6 | |
| Diphenylamine SCHEMBL28192462 | 0.77 | HSD17B10 (0.67) | HSD17B10ALDH1A1ALOX12TSHRTDP1 | |
| Diphenylamine SCHEMBL3003404 | 0.76 | HSD17B10 (1.00) | HSD17B10ALDH1A1ALOX12TSHRTDP1 | |
| Diphenylamine SCHEMBL1619083 | 0.76 | HSD17B10 (1.00) | HSD17B10ALDH1A1ALOX12TSHRTDP1 | |
| SCHEMBL4785787 | 0.76 | FADS1 (0.45) | ALDH1A1TDP1MAPTKMT2AMEN1 | |
| Diphenylamine SCHEMBL301493 | 0.76 | HSD17B10 (1.00) | HSD17B10ALDH1A1ALOX12TSHRTDP1 | |
| Diphenylamine SCHEMBL229 | 0.76 | HSD17B10 (1.00) | HSD17B10ALDH1A1ALOX12TSHRTDP1 | |
| Diphenylamine SCHEMBL6828443 | 0.76 | HSD17B10 (1.00) | HSD17B10ALDH1A1ALOX12TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115448909-B | N-carbazolyl-1H-pyrrole-2-carboxamide and application thereof as ligand in copper-catalyzed C-N coupling reaction | 中山大学 | 2023-10-27 | — | — | CN | disclosed |
| CN-115448909-A | N-carbazolyl-1H-pyrrole-2-formamide and application thereof as ligand in copper-catalyzed C-N coupling reaction | 中山大学 | 2022-12-09 | — | — | CN | disclosed |
| WO-2022183900-A1 | ORGANIC LIGHT-EMITTING DEVICE HAVING THERMALLY ACTIVATED DELAYED FLUORESCENT MATERIAL AS LIGHT-EMITTING LAYER MATERIAL | 北京大学深圳研究生院 | 2022-09-09 | — | — | WO | disclosed |
| US-11121327-B2 | Spiro-condensed lactam compounds for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2021-09-14 | — | — | US | disclosed |
| US-11121327-B2 | Spiro-condensed lactam compounds for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2021-09-14 | — | — | US | disclosed |
| CN-108530444-B | Novel NAMPT and IDO dual inhibitor and preparation method and medical application thereof | 药康众拓(江苏)医药科技有限公司 | 2021-08-24 | — | — | CN | disclosed |
| EP-3016952-B1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |
| EP-3016952-B1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2019-05-15 | — | — | EP | disclosed |
| US-20160372681-A1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2016-12-22 | — | — | US | disclosed |
| US-20160372681-A1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCK PATENT GMBH (DE) | 2016-12-22 | — | — | US | disclosed |
| US-20030219427-A1 | TPL-2/COT kinase and methods of use | MEDICAL RESEARCH COUNCIL (GB) | 2003-11-27 | — | — | US | disclosed |
| US-20020099169-A1 | TPL-2/COT KINASE AND METHODS OF USE | BASF AKTIENGESELLCHAFT | 2002-07-25 | — | — | US | disclosed |
| CN-1333758-A | Substituted bicyclic derivatives useful as anticancer agents | PFIZER PROD INC (US) | 2002-01-30 | — | — | CN | disclosed |
| US-6235730-B1 | ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT | JAPAN TOBACCO, INC. (JP) | 2001-05-22 | — | — | US | disclosed |
| EP-0970954-A1 | 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME | JAPAN TOBACCO INC. (JP) | 2000-01-12 | — | — | EP | disclosed |
| CN-1028009-C | conductive pigment composite material | KERR MC GEE CHEM CORP (US) | 1995-03-29 | — | — | CN | disclosed |
| US-5106690-A | Method for producing electrically conductive pigmentary composites | KERR-MCGEE CHEMICAL CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| US-5028481-A | Electrically conductive pigmentary composites | KERR-MCGEE CHEMICAL (US) | 1991-07-02 | — | — | US | disclosed |
| CN-1051049-A | ELECTRICALLY CONDUCTIVE PIGMENTARY COMPOSITES | KERR MC GEE CHEM CORP (US) | 1991-05-01 | — | — | CN | disclosed |
| US-4272507-A | Phenylaminothiophenacetic acids, their synthesis, compositions and use | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1981-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11121327-B2 | Spiro-condensed lactam compounds for organic electroluminescent devices | PORCN, COASY, AAAS | HSD17B10 1772/4885ALDH1A1 2105/4885ALOX12 3890/4885 |
| US-20160372681-A1 | SPIRO-CONDENSED LACTAM COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES | PORCN, COASY, AAAS | HSD17B10 1772/4885ALDH1A1 2105/4885ALOX12 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.