Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787173 | 0.80 | KDM4E (0.58) | KDM4ELMNACYP2C19ALDH1A1ALOX15 | |
| SCHEMBL8119209 | 0.78 | KDM4E (0.30) | KDM4ELMNACYP2C19POLB | |
| SCHEMBL11075525 | 0.76 | KDM4E (0.67) | KDM4ELMNACYP2C19TSHRNPSR1 | |
| SCHEMBL13453980 | 0.76 | ALDH1A1 (0.33) | KDM4ELMNACYP2C19ALDH1A1ALOX15 | |
| SCHEMBL7749976 | 0.76 | LMNA (0.34) | KDM4ELMNACYP2C19 | |
| SCHEMBL5858279 | 0.74 | GABRP (0.37) | KDM4ELMNACYP2C19ALDH1A1TSHR | |
| SCHEMBL20204315 | 0.74 | KDM4E (0.33) | KDM4ELMNACYP2C19 | |
| SCHEMBL18434036 | 0.71 | KDM4E (0.33) | KDM4ELMNACYP2C19 | |
| SCHEMBL4977785 | 0.71 | KDM4E (0.31) | KDM4ELMNACYP2C19 | |
| SCHEMBL8107314 | 0.70 | HSD17B10 (0.36) | POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099019-A1 | 6-HYDROXY-DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008099019-A1 | 6-HYDROXY-DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |