Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 5/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 5/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.51 |
| ▸ | PIM1 | P11309 | 4/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.51 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783757 | 0.90 | AKR1C3 (0.51) | KDRCSNK2A2CSNK2BCSNK2A1PIM1 | |
| SCHEMBL4740878 | 0.84 | EGFR (0.51) | KDM4CMEN1KMT2AMAPTHPGD | |
| SCHEMBL4786745 | 0.81 | GAA (0.53) | KDRMEN1KMT2AMAPTHPGD | |
| SCHEMBL4740887 | 0.80 | MEN1 (0.56) | PIM1KDM4CMEN1KMT2AMAPT | |
| SCHEMBL4785974 | 0.80 | FADS1 (0.55) | KDM4CMEN1KMT2AMAPTHPGD | |
| SCHEMBL4810776 | 0.78 | MEN1 (0.43) | KDM4CMEN1KMT2AMAPTHPGD | |
| SCHEMBL4739653 | 0.78 | MEN1 (0.45) | PIM1KDM4CMEN1KMT2AMAPT | |
| SCHEMBL4742065 | 0.78 | FADS1 (0.59) | KDRMEN1KMT2AMAPTHPGD | |
| SCHEMBL4804196 | 0.77 | MAPT (0.44) | CSNK2A2CSNK2BCSNK2A1KDM4CMEN1 | |
| SCHEMBL4738611 | 0.76 | KDM4C (0.48) | KDRKDM4CMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | claimed |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | LEXICON PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | LEXICON PHARMACEUTICALS, INC. | 2008-08-14 | — | — | US | disclosed |
| WO-2008089307-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF PAIN, INFLAMMATION AND CANCER | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008089310-A2 | DELTA 5 DESATURASE INHIBITORS FOR THE TREATMENT OF OBESITY | LEXICON PHARMACEUTICALS, INC. (US) | 2008-07-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194557-A1 | Methods and compositions for the treatment of pain, inflammation and cancer | TNF, IL6, CXCL8 | KDR 1066/4885CSNK2A2 1337/4885CSNK2B 2047/4885 |
| US-20080200458-A1 | Methods and compositions for the treatment of body composition disorders | CPT1B, CPT1A, SHBG | KDR 4840/4885CSNK2A2 1683/4885CSNK2B 1854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.