Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 3/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | GSK3A | P49840 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | ABL2 | P42684 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2096746 | 0.79 | METAP2 (0.51) | HPGDMETAP2GSK3ACDK1CCNB1 | |
| SCHEMBL6524744 | 0.77 | PDE5A (0.48) | KDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL25080893 | 0.76 | PTGER1 (0.49) | DRD1 | |
| SCHEMBL2096744 | 0.76 | METAP2 (0.33) | HPGDMETAP2 | |
| Benzene SCHEMBL27958568 | 0.75 | GUSB (0.45) | KDM4EHPGDSTAT3 | |
| SCHEMBL1502098 | 0.75 | ALOX5AP (0.40) | CDK9CCNT1CDK5 | |
| SCHEMBL1948580 | 0.74 | IDO1 (0.42) | METAP2 | |
| SCHEMBL1949655 | 0.73 | KDM1A (0.48) | HTTMETAP2CDK1 | |
| SCHEMBL4784933 | 0.73 | CA12 (0.38) | HTTNPSR1SMN1; SMN2 | |
| SCHEMBL4786164 | 0.72 | CA2 (0.39) | KDM4ELMNAHPGDHTTGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |