Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 7/20 | 0.34 |
| ▸ | HTR2B | P41595 | 4/20 | 0.34 |
| ▸ | BRD1 | O95696 | 1/20 | 0.32 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4784941 | 0.80 | CA1 (0.40) | CA12CA1CA2CA7CA14 | |
| SCHEMBL4786157 | 0.73 | KDM4E (0.33) | HTTSMN1; SMN2NPSR1 | |
| SCHEMBL2096744 | 0.68 | METAP2 (0.33) | MAPTALOX15ALDH1A1 | |
| SCHEMBL25080893 | 0.65 | PTGER1 (0.49) | KMT2A | |
| SCHEMBL1948708 | 0.65 | CA1 (0.47) | CA12CA1CA2CA7MEN1 | |
| SCHEMBL2096746 | 0.65 | METAP2 (0.51) | CA12CA1CA2CA7CA14 | |
| SCHEMBL2982026 | 0.64 | PNMT (0.48) | CA12CA1CA2CA7CA14 | |
| SCHEMBL6524744 | 0.63 | PDE5A (0.48) | MEN1ALOX15TSHRKMT2ASMN1; SMN2 | |
| SCHEMBL8198838 | 0.63 | CA12 (0.59) | CA12CA1CA2CA7CA14 | |
| SCHEMBL1502098 | 0.62 | ALOX5AP (0.40) | CA1CA2CA7MEN1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |