Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GGT1 | P19440 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2096746 | 0.80 | METAP2 (0.51) | HSD17B10ALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL1950931 | 0.78 | HTT (0.48) | KDM4ETDP1LMNASMN1; SMN2MAPK1 | |
| SCHEMBL5322046 | 0.78 | PDE5A (0.53) | PDE5ATSHRKDM4EPTGS2HSD17B10 | |
| SCHEMBL8676653 | 0.77 | PTGS2 (0.61) | PDE5ATSHRKDM4EPTGS2HSD17B10 | |
| SCHEMBL4786157 | 0.77 | KDM4E (0.33) | KDM4EHPGDLMNASMN1; SMN2 | |
| SCHEMBL2096744 | 0.77 | METAP2 (0.33) | HSD17B10ALDH1A1HPGDGAAALOX15 | |
| SCHEMBL1502098 | 0.76 | ALOX5AP (0.40) | PDE5AHSD17B10ALOX15MEN1KMT2A | |
| Benzene SCHEMBL27958568 | 0.76 | GUSB (0.45) | PDE5AKDM4EHSD17B10ALDH1A1HPGD | |
| SCHEMBL1948580 | 0.75 | IDO1 (0.42) | CYP1A2CYP2C9MAOB | |
| SCHEMBL1947684 | 0.75 | SGMS2 (0.43) | KDM4EALDH1A1HPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575359-B2 | Acid-sensitive linkers for drug delivery | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-11-05 | — | — | US | disclosed |
| US-20110053878-A1 | ACID-SENSITIVE LINKERS FOR DRUG DELIVERY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053878-A1 | ACID-SENSITIVE LINKERS FOR DRUG DELIVERY | CD44, MSN, ABCC1 | PDE5A 4104/4885TSHR 3706/4885KDM4E 4043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.