Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11511432 | 0.74 | LMNA (0.39) | LMNAKDM4EL3MBTL1MAPK1SLC6A2 | |
| SCHEMBL31480056 | 0.72 | LMNA (0.46) | LMNAKDM4EL3MBTL1AOC3MAPK1 | |
| SCHEMBL21158705 | 0.70 | ALDH1A1 (0.41) | LMNAKDM4EL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6522565 | 0.70 | LMNA (0.44) | LMNAKDM4EL3MBTL1AOC3MAPK1 | |
| SCHEMBL1674631 | 0.69 | KDM4E (0.58) | LMNAKDM4EAOC3SLC6A2SLC6A4 | |
| SCHEMBL8508318 | 0.65 | SMN1; SMN2 (0.42) | LMNAALDH1A1TSHRSMN1; SMN2ADRA2A | |
| SCHEMBL2336389 | 0.64 | — | — | |
| SCHEMBL6045285 | 0.64 | — | — | |
| SCHEMBL26067052 | 0.64 | — | — | |
| SCHEMBL23337668 | 0.64 | LMNA (0.50) | LMNAKDM4EAOC3MAPK1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132464-A2 | MEK5 AND RELATED PROTEINS AS BIOMARKERS OF NEURODEGENERATIVE DISEASES | THE UNIVERSITY OF NOTTINGHAM (GB) | 2008-11-06 | — | — | WO | disclosed |