Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787718 | 0.91 | TSHR (0.41) | TSHRGFERPOLBLMNAALDH1A1 | |
| SCHEMBL4745393 | 0.84 | KDM4E (0.45) | TSHRPOLBLMNAALDH1A1HTT | |
| SCHEMBL4784036 | 0.84 | TSHR (0.67) | TSHRGFERPOLBLMNAALDH1A1 | |
| SCHEMBL4745387 | 0.80 | TSHR (0.51) | TSHRGFERPOLBLMNAALDH1A1 | |
| SCHEMBL4787200 | 0.80 | TSHR (0.43) | TSHRGFERPOLBLMNAALDH1A1 | |
| SCHEMBL4787431 | 0.80 | IDO1 (0.47) | TSHRGFERPOLBLMNAALDH1A1 | |
| SCHEMBL4746814 | 0.78 | TP53 (0.43) | TSHRPOLBALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL4746166 | 0.78 | TSHR (0.43) | TSHRGFERPOLBLMNAALDH1A1 | |
| SCHEMBL4786482 | 0.77 | TSHR (0.42) | TSHRGFERPOLBLMNAALDH1A1 | |
| SCHEMBL4786432 | 0.77 | TSHR (0.42) | TSHRGFERPOLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | disclosed |