Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.36 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788634 | 0.91 | SMN1; SMN2 (0.48) | TSHRMAPTPOLBALDH1A1LMNA | |
| SCHEMBL4786482 | 0.90 | TSHR (0.42) | TSHRGFERPOLBALDH1A1LMNA | |
| SCHEMBL4743050 | 0.89 | TSHR (0.44) | TSHRGFERMAPTPOLBALDH1A1 | |
| SCHEMBL4786432 | 0.88 | TSHR (0.42) | TSHRGFERPOLBALDH1A1LMNA | |
| SCHEMBL4787431 | 0.86 | IDO1 (0.47) | TSHRGFERMAPTPOLBALDH1A1 | |
| SCHEMBL4788023 | 0.80 | TSHR (0.43) | TSHRGFERMAPTPOLBLMNA | |
| SCHEMBL4787944 | 0.80 | SMN1; SMN2 (0.48) | TSHRMAPTPOLBALDH1A1LMNA | |
| SCHEMBL4746863 | 0.80 | MAPT (0.45) | TSHRMAPTPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL4786708 | 0.79 | MAPT (0.46) | MAPTPOLBALDH1A1LMNAHTT | |
| SCHEMBL4787284 | 0.78 | TSHR (0.52) | TSHRGFERPOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115259-A2 | DERIVATIVES OF BENZOXADIAZOLE SUITABLE FOR THE TREATMENT OF CELL PROLIFERATIVE DISEASES | RIGEL PHARMACEUTICALS, INC. (US) | 2008-09-25 | — | — | WO | claimed |