Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.40 |
| ▸ | CDK1 | P06493 | 4/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.40 |
| ▸ | CDK2 | P24941 | 4/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740757 | 0.89 | PIK3CD (0.39) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL4737408 | 0.85 | ADORA2A (0.40) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL4739903 | 0.85 | PIK3CA (0.41) | BRD4PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL4740441 | 0.84 | MEN1 (0.39) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL4786839 | 0.80 | PIKFYVE (0.39) | CCNT1CCNB2CCNE2CDK1CCNB1 | |
| SCHEMBL4739040 | 0.80 | PIK3CD (0.35) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL4787389 | 0.78 | ADORA2A (0.39) | — | |
| SCHEMBL4787513 | 0.78 | SLC40A1 (0.40) | PIK3CDPIK3CGPIK3CAPIK3CB | |
| SCHEMBL4740427 | 0.77 | PLAU (0.39) | DRD2HTR2AHTR2CDRD3HTR6 | |
| SCHEMBL14148284 | 0.76 | ADORA1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |