Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4740757 | 0.94 | PIK3CD (0.39) | ADORA2AADORA1PIK3CDPIK3CGPIK3CA | |
| SCHEMBL4787513 | 0.92 | SLC40A1 (0.40) | ADORA2AADORA1PIK3CDPIK3CGPIK3CA | |
| SCHEMBL4740427 | 0.91 | PLAU (0.39) | ADORA2AADORA1PIK3CBDRD2HTR2A | |
| SCHEMBL4740441 | 0.90 | MEN1 (0.39) | ADORA2AADORA1PIK3CDPIK3CGPIK3CA | |
| SCHEMBL4737526 | 0.89 | SLC22A12 (0.40) | ADORA2AADORA1PIK3CAMTORDRD2 | |
| SCHEMBL14148288 | 0.88 | ADORA2A (0.34) | ADORA2AADORA1NTRK1PIK3CDPIK3CG | |
| SCHEMBL4739916 | 0.88 | GLO1 (0.41) | ADORA2AADORA1SLC40A1 | |
| SCHEMBL4741151 | 0.87 | KDM1A (0.39) | ADORA2AADORA1PIK3CAMTOR | |
| SCHEMBL4736835 | 0.85 | CCNT1 (0.40) | PIK3CDPIK3CGPIK3CAPIK3CBMTOR | |
| SCHEMBL4739040 | 0.85 | PIK3CD (0.35) | ADORA2AADORA1PIK3CDPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |