Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28929654 | 0.82 | LMNA (0.43) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL4321608 | 0.82 | MAPT (0.58) | MAPTALDH1A1NPC1LMNASMN1; SMN2 | |
| SCHEMBL19284321 | 0.81 | NR4A2 (0.50) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL31454215 | 0.78 | ALDH1A1 (0.56) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL28789909 | 0.78 | NPC1 (0.43) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL1541405 | 0.77 | GABRB2 (0.60) | MAPTALDH1A1GAANPC1RAB9A | |
| SCHEMBL2883370 | 0.76 | NOTUM (0.66) | MAPTALDH1A1GAAGABRA2GABRB2 | |
| SCHEMBL2399420 | 0.76 | NPC1 (0.57) | MAPTALDH1A1NPC1RAB9ATSHR | |
| SCHEMBL8443848 | 0.75 | SCN3A (0.49) | ALDH1A1GAALMNAKDM4E | |
| SCHEMBL15848888 | 0.75 | EPHX2 (0.57) | MAPTALDH1A1LMNATSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008157844-A1 | NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-12-24 | — | — | WO | disclosed |