Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 6/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MPI | P34949 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 2/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.39 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.39 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741223 | 0.75 | TYMS (0.62) | TYMSMAPTTP53DHFRKDM4E | |
| SCHEMBL4737442 | 0.74 | MAPT (0.41) | BRAFMAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL4741268 | 0.73 | TYMS (0.57) | TYMSMAPTTP53DHFRKDM4E | |
| SCHEMBL4741122 | 0.71 | TYMS (0.55) | TYMSMAPTKDM4EALDH1A1MPI | |
| SCHEMBL7237418 | 0.71 | FYN (0.65) | BRAFLCKMAPTTP53KDM4E | |
| SCHEMBL4739002 | 0.70 | TYMS (0.51) | TYMSMAPTKDM4EALDH1A1MPI | |
| SCHEMBL12391883 | 0.67 | HIF1A (0.54) | EGFRMEN1KMT2A | |
| SCHEMBL6652286 | 0.66 | TYMS (1.00) | TYMS | |
| SCHEMBL6997904 | 0.66 | FYN (0.61) | BRAFLCKMAPTTP53KDM4E | |
| Hydrochloric Acid SCHEMBL6844303 | 0.65 | TYMS (0.98) | TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |