Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738561 | 0.83 | TSHR (0.48) | MAPTALDH1A1NPSR1TSHRSMN1; SMN2 | |
| SCHEMBL4741216 | 0.77 | TYMS (0.53) | ALDH1A1 | |
| SCHEMBL4741147 | 0.77 | ALDH1A1 (0.45) | ALDH1A1NPSR1TSHRSMN1; SMN2MEN1 | |
| SCHEMBL4741212 | 0.75 | KMT2A (0.49) | MAPTKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL4787478 | 0.74 | TYMS (0.49) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL4787519 | 0.73 | TSHR (0.46) | MAPTKDM4EALDH1A1TSHRLMNA | |
| SCHEMBL4736846 | 0.68 | TSHR (0.41) | MAPTKDM4ETSHRSMN1; SMN2LMNA | |
| SCHEMBL14147958 | 0.67 | SMN1; SMN2 (0.42) | KDM4ECYP1A2CYP2C19ALDH1A1TSHR | |
| SCHEMBL4739051 | 0.66 | ADORA2A (0.48) | MAPTKDM4ECYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL14147957 | 0.66 | ADORA2A (0.42) | MAPTKDM4ECYP1A2CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |