Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 9/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | CCR2 | P41597 | 3/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737408 | 0.92 | ADORA2A (0.40) | SLC40A1PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4739916 | 0.89 | GLO1 (0.41) | SLC40A1KDM1AMAOACCR2ADORA2A | |
| SCHEMBL14148288 | 0.89 | ADORA2A (0.34) | SLC40A1KDM1APIK3CDPIK3CAPIK3CB | |
| SCHEMBL4740427 | 0.89 | PLAU (0.39) | PIK3CBADORA2AADORA1 | |
| SCHEMBL4740757 | 0.86 | PIK3CD (0.39) | SLC40A1KDM1ACCR2PIK3CDPIK3CA | |
| SCHEMBL4737526 | 0.85 | SLC22A12 (0.40) | PIK3CAADORA2AADORA1 | |
| SCHEMBL4741151 | 0.84 | KDM1A (0.39) | KDM1ACCR2PIK3CAADORA2AADORA1 | |
| SCHEMBL4740441 | 0.82 | MEN1 (0.39) | PIK3CDPIK3CAPIK3CGADORA2AADORA1 | |
| SCHEMBL14148281 | 0.81 | PIK3CA (0.48) | CCR2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4739040 | 0.79 | PIK3CD (0.35) | KDM1APIK3CDPIK3CAPIK3CGADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |