Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | CCR9 | P51686 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ATIC | P31939 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ACLY | P53396 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739916 | 0.91 | GLO1 (0.41) | SLC22A12GLO1CCR9ADORA2AADORA1 | |
| SCHEMBL4737408 | 0.89 | ADORA2A (0.40) | PIK3CAMTORDRD2HTR2AHTR2C | |
| SCHEMBL4740427 | 0.86 | PLAU (0.39) | GLO1DRD2HTR2AHTR2CDRD3 | |
| SCHEMBL4787513 | 0.85 | SLC40A1 (0.40) | PIK3CAADORA2AADORA1 | |
| SCHEMBL14148288 | 0.85 | ADORA2A (0.34) | PIK3CAGLO1DRD2HTR2AHTR2C | |
| SCHEMBL4740757 | 0.83 | PIK3CD (0.39) | PIK3CADRD2HTR2AHTR2CDRD3 | |
| SCHEMBL4741151 | 0.81 | KDM1A (0.39) | PIK3CAMTORGLO1ADORA2AADORA1 | |
| SCHEMBL14148281 | 0.80 | PIK3CA (0.48) | PIK3CAMTORPIK3C3 | |
| SCHEMBL4740441 | 0.79 | MEN1 (0.39) | PIK3CAMTORDRD2HTR2AHTR2C | |
| SCHEMBL4736841 | 0.78 | NFKBIA (0.42) | PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |