Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737408 | 0.91 | ADORA2A (0.40) | PIK3CBADORA2AADORA1HTR6DRD2 | |
| SCHEMBL4787513 | 0.89 | SLC40A1 (0.40) | PIK3CBADORA2AADORA1 | |
| SCHEMBL4737526 | 0.86 | SLC22A12 (0.40) | ADORA2AADORA1GLO1HTR6DRD2 | |
| SCHEMBL4740757 | 0.86 | PIK3CD (0.39) | PIK3CBADORA2AADORA1MEN1KMT2A | |
| SCHEMBL4739916 | 0.85 | GLO1 (0.41) | ADORA2AADORA1GLO1 | |
| SCHEMBL14148288 | 0.85 | ADORA2A (0.34) | PIK3CBADORA2AADORA1GLO1HTR6 | |
| SCHEMBL4741151 | 0.84 | KDM1A (0.39) | ADORA2AADORA1MEN1KMT2AGLO1 | |
| SCHEMBL4740441 | 0.82 | MEN1 (0.39) | ADORA2AADORA1MEN1KMT2APGAM1 | |
| SCHEMBL14148281 | 0.81 | PIK3CA (0.48) | PIK3CB | |
| SCHEMBL4739040 | 0.80 | PIK3CD (0.35) | ADORA2AADORA1HTR6DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |