Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4741212 | 0.88 | KMT2A (0.49) | TSHRALDH1A1GAANPBWR1KMT2A | |
| SCHEMBL4738561 | 0.80 | TSHR (0.48) | TSHRALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL4737442 | 0.73 | MAPT (0.41) | TSHRALDH1A1GAAKMT2AKDM4E | |
| SCHEMBL4741216 | 0.73 | TYMS (0.53) | ALDH1A1 | |
| SCHEMBL4741147 | 0.72 | ALDH1A1 (0.45) | TSHRALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL897635 | 0.64 | ALDH1A1 (0.58) | TSHRALDH1A1GAANPBWR1KMT2A | |
| SCHEMBL10570472 | 0.63 | TSHR (0.89) | TSHRALDH1A1GAANPBWR1KMT2A | |
| SCHEMBL10155932 | 0.62 | MCOLN3 (0.72) | TSHRALDH1A1GAANPBWR1KMT2A | |
| SCHEMBL14147958 | 0.62 | SMN1; SMN2 (0.42) | TSHRALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL4739051 | 0.61 | ADORA2A (0.48) | ALDH1A1GAAKMT2AKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |