Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738561 | 0.83 | TSHR (0.48) | ALDH1A1TSHRSMN1; SMN2HSD17B10NPSR1 | |
| SCHEMBL4741216 | 0.79 | TYMS (0.53) | ALDH1A1 | |
| SCHEMBL4737442 | 0.77 | MAPT (0.41) | ALDH1A1TSHRSMN1; SMN2HSD17B10NPSR1 | |
| SCHEMBL4741212 | 0.74 | KMT2A (0.49) | ALDH1A1TSHRKMT2AMEN1POLB | |
| SCHEMBL4787519 | 0.72 | TSHR (0.46) | ALDH1A1TSHRHSD17B10KMT2AMEN1 | |
| SCHEMBL10156486 | 0.68 | ALDH1A1 (0.63) | ALDH1A1TSHRNPSR1HTTKMT2A | |
| SCHEMBL23847020 | 0.68 | ALDH1A1 (0.63) | ALDH1A1TSHRNPSR1KMT2ABRD4 | |
| SCHEMBL30511773 | 0.68 | ALDH1A1 (0.63) | ALDH1A1TSHRNPSR1KMT2ABRD4 | |
| SCHEMBL30511774 | 0.68 | ALDH1A1 (0.63) | ALDH1A1TSHRNPSR1KMT2ABRD4 | |
| SCHEMBL4736846 | 0.68 | TSHR (0.41) | TSHRSMN1; SMN2HSD17B10HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |