Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | DRD1 | P21728 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.47 |
| ▸ | DRD5 | P21918 | 3/20 | 0.47 |
| ▸ | DRD3 | P35462 | 3/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 9/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4750457 | 0.78 | HTR2C (0.41) | HRH1KDM4ESMN1; SMN2 | |
| SCHEMBL4788942 | 0.77 | GABRA1 (0.34) | KDM4E | |
| SCHEMBL4789082 | 0.73 | TDP1 (0.47) | HRH1DRD1DRD4DRD5DRD3 | |
| Ammonia Solution, Strong SCHEMBL4789081 | 0.72 | TDP1 (0.46) | HRH1DRD1DRD4DRD5DRD3 | |
| Lithium Ion SCHEMBL4750393 | 0.67 | SIGMAR1 (0.39) | DRD2 | |
| SCHEMBL4788836 | 0.66 | HRH3 (0.54) | DRD3DRD2TDP1TSHRSMN1; SMN2 | |
| SCHEMBL7012697 | 0.65 | KDM4E (0.84) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL8773745 | 0.64 | HRH1 (1.00) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL29573150 | 0.64 | TDP1 (0.66) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL30150794 | 0.64 | LTA4H (0.73) | HRH1DRD1DRD4DRD5DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |