Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.50 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.45 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.44 |
| ▸ | BMX | P51813 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789714 | 0.91 | BRAF (0.48) | BRAFCSF1RABL1SRCDDR1 | |
| SCHEMBL4789788 | 0.90 | BMX (0.46) | BRAFCSF1RABL1SRCDDR1 | |
| SCHEMBL4789707 | 0.89 | BRAF (0.47) | BRAFBTKABL1MEN1KMT2A | |
| SCHEMBL4789715 | 0.88 | BMX (0.58) | BRAFBTKMAPK14KCNQ3KCNQ2 | |
| SCHEMBL4788891 | 0.87 | CSF1R (0.61) | BRAFCSF1RBTKABL1SRC | |
| SCHEMBL4788095 | 0.84 | BRAF (0.63) | BRAFCSF1RBTKDDR1MAPK14 | |
| SCHEMBL4788857 | 0.83 | BRAF (0.52) | BRAFABL1SRCDDR1MAPK14 | |
| SCHEMBL4788672 | 0.83 | LMNA (0.50) | BRAFCSF1RABL1SRCDDR1 | |
| SCHEMBL4789713 | 0.82 | BMX (0.41) | BRAFCSF1RABL1SRCDDR1 | |
| SCHEMBL4788647 | 0.81 | LCK (0.46) | BRAFCSF1RABL1SRCDDR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |