Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.50 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.47 |
| ▸ | HTR7 | P34969 | 5/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4786772 | 0.88 | MTNR1A (0.49) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4787985 | 0.87 | MTNR1A (0.48) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4788313 | 0.84 | KCNH2 (0.55) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4785773 | 0.80 | KCNH2 (0.72) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4788501 | 0.80 | KCNH2 (0.72) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL841303 | 0.76 | SCN9A (0.71) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL840155 | 0.76 | SCN9A (0.57) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4786571 | 0.74 | KCNH2 (0.47) | KCNH2SCN9ASCN5ADRD2SMN1; SMN2 | |
| SCHEMBL4787682 | 0.74 | HTR7 (0.51) | KCNH2SCN9ASCN5AMTNR1AMTNR1B | |
| SCHEMBL4788581 | 0.72 | HTR7 (0.47) | MTNR1AMTNR1BHTR7CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |