Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | BAD | Q92934 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787977 | 0.83 | L3MBTL1 (0.40) | HPGDALDH1A1HTTCYP3A4CYP2C9 | |
| SCHEMBL4788901 | 0.77 | ALDH1A1 (0.48) | HPGDALDH1A1LMNATSHRNPC1 | |
| SCHEMBL3456196 | 0.75 | HPGD (1.00) | HPGDALDH1A1HTTCYP3A4CYP2C9 | |
| SCHEMBL4786769 | 0.74 | KDM4E (0.46) | ALDH1A1HTTCYP2C19KMT2APOLB | |
| SCHEMBL14825154 | 0.72 | HPGD (0.79) | HPGDALDH1A1HTTCYP3A4CYP2C9 | |
| SCHEMBL16588035 | 0.71 | HTT (0.76) | HPGDALDH1A1HTTCYP3A4CYP2C9 | |
| SCHEMBL7245369 | 0.68 | TSHR (0.37) | ALDH1A1HTTKMT2APOLBLMNA | |
| SCHEMBL4212502 | 0.68 | TSHR (0.37) | ALDH1A1HTTKMT2APOLBLMNA | |
| SCHEMBL3455489 | 0.67 | HPGD (0.65) | HPGDALDH1A1HTTCYP3A4CYP2C9 | |
| SCHEMBL11375807 | 0.67 | HPGD (1.00) | HPGDALDH1A1HTTCYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |