Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789100 | 1.00 | HTR1A (0.31) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL4749973 | 0.73 | METAP2 (0.35) | HTR1ADRD2 | |
| SCHEMBL4749974 | 0.73 | METAP2 (0.35) | HTR1ADRD2 | |
| SCHEMBL4788607 | 0.73 | CNR2 (0.36) | DRD2HTR2A | |
| SCHEMBL4788597 | 0.73 | CNR2 (0.36) | DRD2HTR2A | |
| SCHEMBL873501 | 0.70 | DRD2 (0.54) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL873500 | 0.70 | DRD2 (0.54) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL14157832 | 0.70 | DRD2 (0.54) | HTR1ADRD2DRD1HTR1BHTR2A | |
| SCHEMBL4839911 | 0.70 | DRD2 (0.54) | HTR1ADRD2DRD1HTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL8823809 | 0.69 | DRD2 (0.53) | HTR1ADRD2DRD1HTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |