Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.39 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.39 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4788368 | 0.82 | HTR6 (0.57) | HTR6HDAC1HDAC10HDAC8HDAC6 | |
| SCHEMBL4031362 | 0.80 | CFTR (0.44) | CFTRMAPTBRD4KCNH2MEN1 | |
| SCHEMBL3355292 | 0.76 | HTR6 (0.59) | HTR6POLBMAPTHTTRXFP1 | |
| SCHEMBL31661395 | 0.72 | CFTR (0.51) | POLBCFTRMAPTBRD4LMNA | |
| SCHEMBL3509099 | 0.72 | CFTR (0.51) | POLBCFTRMAPTBRD4LMNA | |
| SCHEMBL4029748 | 0.70 | CNR2 (0.55) | CFTRMAPTMEN1LMNAKMT2A | |
| SCHEMBL917196 | 0.69 | BRD4 (0.51) | POLBCFTRMAPTBRD4MEN1 | |
| SCHEMBL3648477 | 0.69 | CFTR (0.46) | POLBCFTRMAPTMEN1LMNA | |
| SCHEMBL29377752 | 0.66 | GLS (0.62) | POLBCFTR | |
| SCHEMBL938567 | 0.66 | GLS (0.62) | POLBCFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134354-A1 | TNF-α PRODUCTION INHIBITOR | ARRAY BIOPHARMA, INC. (US) | 2008-11-06 | — | — | WO | disclosed |