Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL698362 | 0.79 | LMNA (0.40) | — | |
| SCHEMBL20384981 | 0.78 | TSHR (0.41) | SIGMAR1TSHRACHE | |
| SCHEMBL2198610 | 0.78 | TSHR (0.41) | SIGMAR1TSHRACHE | |
| Hydrochloric Acid SCHEMBL28328614 | 0.75 | TSHR (0.38) | SIGMAR1TSHRACHE | |
| SCHEMBL2620728 | 0.73 | ACHE (0.50) | SIGMAR1TSHRACHE | |
| SCHEMBL60023 | 0.72 | — | — | |
| SCHEMBL13367414 | 0.71 | TSHR (0.46) | SIGMAR1TSHRACHEMAPK13MAPK12 | |
| SCHEMBL13367468 | 0.70 | CSF1R (0.45) | SIGMAR1TSHRACHEMAPK13MAPK12 | |
| Hydroquinone SCHEMBL28096005 | 0.70 | HSD17B1 (0.42) | SIGMAR1TSHR | |
| SCHEMBL3894433 | 0.70 | ALDH1A1 (0.39) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1618098-A4 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE | PCT THERAPEUTICS INC (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1618098-A2 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE | PCT Therapeutics Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| WO-2004091502-A2 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2004-10-28 | — | — | WO | disclosed |