Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 10/20 | 0.53 |
| ▸ | PPARD | Q03181 | 5/20 | 0.53 |
| ▸ | PPARG | P37231 | 13/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700424 | 0.81 | PPARA (0.64) | PPARAPPARDPPARGKDM4EALDH1A1 | |
| SCHEMBL5451 | 0.75 | SMN1; SMN2 (0.51) | NPC1RAB9AKDM4EALDH1A1TP53 | |
| SCHEMBL30283197 | 0.75 | SMN1; SMN2 (0.51) | NPC1RAB9AKDM4EALDH1A1TP53 | |
| SCHEMBL21939443 | 0.74 | L3MBTL1 (0.59) | PPARAPPARGKDM4EALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL27764098 | 0.73 | NPC1 (0.50) | NPC1RAB9AKDM4EALDH1A1TP53 | |
| Acetoacetic Acid SCHEMBL27513054 | 0.72 | SMN1; SMN2 (0.52) | NPC1RAB9AKDM4EALDH1A1TP53 | |
| SCHEMBL4692295 | 0.72 | PPARA (0.66) | PPARAPPARDPPARGRAB9AALDH1A1 | |
| SCHEMBL28020073 | 0.70 | SMN1; SMN2 (0.47) | NPC1RAB9AKDM4EALDH1A1TP53 | |
| SCHEMBL7824870 | 0.69 | PPARA (0.52) | PPARAPPARDPPARGKDM4EALDH1A1 | |
| SCHEMBL14602138 | 0.69 | PPARA (0.50) | PPARAPPARDPPARGRAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758582-A4 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1758582-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006002349-A1 | AMIDO COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-01-05 | — | — | WO | disclosed |