Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30283197 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL27764098 | 0.98 | NPC1 (0.50) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL3942263 | 0.91 | NPC1 (0.46) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL1132618 | 0.85 | PIP4K2A (0.48) | ALDH1A1GAAARPOLBNPSR1 | |
| SCHEMBL20607680 | 0.85 | NPC1 (0.47) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL973234 | 0.84 | ALDH1A1 (0.54) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 | |
| Acetoacetic Acid SCHEMBL27513054 | 0.83 | SMN1; SMN2 (0.52) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL13857771 | 0.82 | ALDH1A1 (0.53) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL1444254 | 0.82 | CYP1A2 (0.55) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 | |
| SCHEMBL21728082 | 0.82 | AR (0.43) | SMN1; SMN2MAPK1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 244 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240400556-A1 | AMIDOPYRIMIDONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-12-05 | — | — | US | claimed |
| CN-115043845-B | Synthesis method of sildenafil | 江苏大学 | 2023-11-10 | — | — | CN | claimed |
| US-20230227449-A1 | AMIDOPYRIMIDONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-07-20 | — | — | US | claimed |
| CN-116375549-A | Method and system for synthesizing amide compound from nitrile compound | 深圳湾实验室 | 2023-07-04 | — | — | CN | claimed |
| EP-4168394-A1 | AMIDOPYRIMIDONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-26 | — | — | EP | claimed |
| CN-115867541-A | Aminopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-03-28 | — | — | CN | claimed |
| CN-115043845-A | Synthesis method of sildenafil | 江苏大学 | 2022-09-13 | — | — | CN | claimed |
| WO-2021259815-A1 | AMIDOPYRIMIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2021-12-30 | — | — | WO | claimed |
| EP-1732922-A1 | METHODS FOR MINIMIZING THIOAMIDE IMPURITIES | Wyeth (US) | 2006-12-20 | — | — | EP | claimed |
| WO-2005100347-A1 | METHODS FOR MINIMIZING THIOAMIDE IMPURITIES | WYETH (US) | 2005-10-27 | — | — | WO | claimed |
| US-20250361338-A1 | PROCESS FOR THE SYNTHESIS OF POLYETHYLENES OR COPOLYMERS OF ETHYLENE AND 1,3-DIENE HAVING A TERMINAL KETONE FUNCTION | MICHELIN & CIE (FR) | 2025-11-27 | — | — | US | disclosed |
| US-20250129016-A1 | PHOTOREDOX METHODS FOR RADIOCYANATION OF ARENES AND USE THEREOF | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2025-04-24 | — | — | US | disclosed |
| CN-116332733-B | Dapagliflozin middle Synthesis process of intermediate | 江苏阿尔法药业股份有限公司 | 2025-02-11 | — | — | CN | disclosed |
| CN-119343386-A | Synthesis of polyethylene or copolymer of ethylene and 1, 3-diene having terminal ketone function | 米其林集团总公司 | 2025-01-21 | — | — | CN | disclosed |
| US-20240400556-A1 | AMIDOPYRIMIDONE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-12-05 | — | — | US | disclosed |
| CN-1139435-A | New ginkgolide derivatives and process for preparing them | SUNKYONG IND LTD (KR) | 1997-01-01 | — | — | CN | disclosed |
| EP-0711762-A1 | PROCESS FOR PRODUCING TETRAZOLE COMPOUND AND INTERMEDIATE THEREFOR | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1996-05-15 | — | — | EP | disclosed |
| EP-0286889-B1 | PROCESS FOR THE PREPARATION OF ORTHO-SUBSTITUTED ARYLCARBOXIMIDO ESTERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-08-21 | — | — | EP | disclosed |
| US-4843167-A | Process for the preparation of ortho-substituted arylcarboximidoesters | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-06-27 | — | — | US | disclosed |
| EP-0286889-A1 | Process for the preparation of ortho-substituted arylcarboximido esters | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250129016-A1 | PHOTOREDOX METHODS FOR RADIOCYANATION OF ARENES AND USE THEREOF | RCC2, PPOX, FTO | SMN1; SMN2 4756/4885MAPK1 2762/4885NPC1 2076/4885 |
| US-20230227449-A1 | AMIDOPYRIMIDONE DERIVATIVES | F12, XDH, CYP3A43 | SMN1; SMN2 3227/4885MAPK1 1740/4885NPC1 2883/4885 |
| US-20240400556-A1 | AMIDOPYRIMIDONE DERIVATIVES | F12, XDH, CYP3A43 | SMN1; SMN2 3227/4885MAPK1 1740/4885NPC1 2883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.