Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 3/20 | 0.39 |
| ▸ | GPR68 | Q15743 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.39 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22084443 | 0.79 | BACE1 (0.40) | BACE1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL29922357 | 0.79 | BACE1 (0.65) | BACE1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL396451 | 0.79 | BACE1 (0.65) | BACE1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL18930965 | 0.74 | HSD17B10 (0.53) | BACE1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL7164883 | 0.73 | BACE1 (0.56) | BACE1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL30464743 | 0.72 | HSD17B10 (0.71) | BACE1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL4571036 | 0.72 | HSD17B10 (0.71) | BACE1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL19790198 | 0.72 | PTGER4 (0.43) | HSD17B10KDM4EHPGD | |
| SCHEMBL7169755 | 0.72 | BACE1 (0.51) | BACE1HSD17B10KDM4EHPGDTSHR | |
| SCHEMBL21137032 | 0.72 | CYP3A4 (0.34) | HSD17B10KDM4EHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2012779-B1 | PROCESS FOR THE PREPARATION OF INDAZOLYL UREAS THAT INHIBIT VANILLOID SUBTYPE 1 (VR1) RECEPTORS | ABBOTT LAB (US) | 2012-05-16 | — | — | EP | disclosed |